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Common symptoms of acid reflux include: A burning sensation in the chest (especially after meals) Regurgitation of food or sour liquid A lump-in-the-throat feeling Bloating and burping Nausea This typically happens when the lower esophageal sphincter (LES), the valve-like muscle that seals off the stomach from the esophagus, becomes weak or relaxed at the wrong time
This process involves the interaction of many mechanisms, including excitatory amino acid toxicity, free radical release, neuronal apoptosis, necrosis, autophagy, over-activation of inflammatory response (Qin, et al
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